Oxidative status in sickle cell anemia

177 xxx They analyzed 651 patients with APL of whom 72 expressed CD56 (11%). CD56 + APL was significantly associated with high white blood cell counts, low albumin levels, the BCR3 isoform and coexpression of the CD2, CD34, CD7, HLA-DR, CD15 and CD117 antigens. For CD56 + APL, the 5-year relapse rate was 22% compared with a 10% relapse rate for CD56-APL (p-value = 0.006). CD56 + APL also showed a greater risk of extramedullary relapse (p-value < 0.001). The relationship between the expression of CD56 and treatment outcome has also been analyzed in acute lymphoblastic leukemia (ALL). Ravandi et al. (7) demonstrated a high incidence of infiltration of the central nervous system in adult patients with ALL. Dalmazzo et al., (8) analyzing T-cell ALL, reported that patients expressing CD56 were older, expressed cytotoxic molecules at a higher frequency and presented shorter OS compared to CD56-patients. Taken together the existing published data suggest that the expression of CD56 is associated with worse prognosis in acute leukemias and the manuscript by Alegretti et al., corroborates reports from different countries. Nevertheless, the mechanisms underlying this association are unclear. Moreover, it is not clear whether CD56 + AML patients should receive a more intense treatment than those that do not express CD56. At present, this matter should be considered with caution, but, definitely there is opportunity for future multicentric clinical trials to address this issue. classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. et al. Mixed-phenotype acute leukemia: clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification. Silla LM, et al. The expression of CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemia. Extramedullary infiltrates of AML are associated with CD56 expression, 11q23 abnormalities and inferior clinical outcome. of the neural cell adhesion molecule CD56 is associated with short remission duration and survival in acute myeloid leukemia with t Groups. Clinical significance of CD56 expression in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based regimens. The presence of CD56/CD16 in T-cell acute lymphoblastic leukaemia correlates with the expression of cytotoxic molecules and is associated with worse response to treatment. HbS polymerization is a primary pathophysiological event in sickle cell anemia (SCA). Hydroxyurea (HU) is one important therapy that offers broad benefits to a select group of patients with severe symptoms. HU induces higher levels …